In late October 2025, the U.S. Food and Drug Administration (FDA) reversed its previous position and confirmed that nicotinamide mononucleotide (NMN) can legally be used in dietary supplements.
This marks a major shift. In late 2022, NMN was temporarily removed from many U.S. platforms (including Amazon) due to its status being linked to pharmaceutical trial investigations. The result was confusion among consumers and a rapid disappearance of NMN from American retailers.
Now, NMN is back — but the market is not the same as before.
More NMN Brands Will Return — But Quality Will Vary Widely
Unlike Canada, the United States does not require supplement brands to undergo pre-approval testing before selling a product. This means U.S. NMN supplements can vary significantly in terms of:
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Ingredient purity
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Bioavailability
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Manufacturing standards
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Authenticity of NMN content
Simply put: the label does not always match the bottle.
This is why many consumers are now turning to Canadian NMN brands for reliability and transparency.
WHY CANADA’S NPN STANDARD IS THE HIGHEST IN THE WORLD
LEVEL | REGION | WHY
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TOP | Canada (Health Canada — NPN) | Requires pre-market approval, clinical evidence, product identity verification, and a safety review before sale.
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HIGH | Australia (TGA) | Strong oversight, but some supplements can be self-certified without pre-approval.
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MEDIUM | European Union | Regulations vary by member state, resulting in moderate oversight.
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LOWEST | USA (FDA supplements) | No pre-approval required; safety is evaluated only after products are on the market.
Why Canadian NPN Regulation Matters
In Canada, NMN supplements are regulated under Health Canada’s Natural Product Number (NPN) system.
To receive an NPN, a product must provide:
✅ Ingredient identity verification
✅ Scientific evidence of safety
✅ Verified dosing
✅ Proof of manufacturing quality (GMP)
This ensures the product is exactly what it claims to be.
How Ensonkan NMN + PQQ Stands Apart
At Ensonkan, we developed our NMN formula with purity, stability, and real effectiveness in mind.
Ensonkan NMN + PQQ:
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Contains pharmaceutical-grade NMN
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Uses stabilized NMN to protect against oxidation (a key quality issue in many bulk powders)
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Includes PQQ to support mitochondrial energy and cognitive vitality
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Is manufactured in cGMP-certified pharmaceutical graded facilities in Canada
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Is licensed by Health Canada (NPN)
This means every bottle meets regulatory and scientific standards — not marketing trends.
What This Means for Customers Moving Forward
The return of NMN to the U.S. market is good news for the longevity community — but also a reminder:
Quality matters. Source matters. Testing matters.
If you are investing in your longevity and cellular energy, it’s worth choosing a supplement backed by:
✔ Transparent sourcing
✔ Regulatory integrity
✔ Research-based formulation
Because the supplement you take every day should be one you trust.
Explore Ensonkan® NMN + PQQ
Shop Canada’s regulated & clinically backed NMN formulation:
🛒 www.ensonkan.ca